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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

Consensus

What Does the Indian Consensus Statement for Rheumatology Say About Pneumococcal Vaccination in Patients With Rheumatologic Diseases?

   

With the availability of PCV13, it is essential for the rheumatologists to know when and which of the 2 pneumococcal vaccines, PCV13 and PPSV23, should be administered to patients with AIRDs. The Indian consensus document for rheumatology serves as a practical guide for the clinicians, providing evidence-based recommendations on vaccination of adult patients with AIRD, aged ≥50 years. Vaccination against IPD is strongly recommended by the consensus guideline. The schedule for administering pneumococcal vaccines in patients with AIRDs is as follows1:

  • PCV13 should be administered first, followed by PPSV23 at >8-week interval

  • If PPSV23 was administered first, then a single dose of PCV13 should be administered after an interval of >1 year

  • If PPSV23 was administered recently, PCV13 should not be given till a minimum gap of 1 year elapses

However, in the Indian context, PCV13 use was approved for adults in 2012. Therefore, it can be presumed that most of the patients with AIRD have already received PPSV23. In such cases, PCV13 can be given to patients with AIRD, with a minimum gap of 1 year post-PPSV23 vaccination.

   

   

AIRD, autoimmune rheumatic disease; IPD, invasive pneumococcal disease; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal plain polysaccharide vaccine.

   

Reference:

Kumar S, Rath P, Malaviya AN. A practical guide to adult vaccination for patients with autoimmune inflammatory rheumatic diseases in India. Indian J Rheumatol. 2017;12:160-168.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

PCV13 in Rheumatology

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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