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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

ACIP 2019

Background

  

In 2014, the ACIP recommended routine use of PCV13 among adults aged ≥65 years.1 As per this recommendation, both PCV13 and PPSV23 should be routinely administered in series to all adults aged ≥65 years.1 The ACIP recommendations for the use of PCV13 (high-risk) in adults aged ≥50 years with immunocompromising conditions, functional or anatomic asplenia, cerebrospinal fluid leak or cochlear implants remain unchanged.2

  

The ACIP recommendations were amended in 2015 to simplify the spacing between PCV13 and PPSV23 in adults aged >65 years.3 The recommendation states that the recommended interval for adults receiving PCV13 and PPSV23 is to be at least 1 year apart, regardless of sequence. In summary, this means that PCV13 is administered first, followed by PPSV23, with a gap of at least 1 year between the two. If an adult above 65 years of age received PPSV23, they will receive PCV13 after 1 year as the older recommendation. The recommended sequence and spacing of PCV13 and PPSV23 in adults aged >65 years is presented in the figure given below.3,4

  

Sequence and Spacing of PCV13 and PPSV23 in Adults Aged >65 Years3

  

Adapted from Kobayashi M, et al. 2015.

The ACIP 2019 guidelines recommend PCV13 for all adults aged ≥65 years based on shared clinical decision-making. This group includes those adults aged ≥65 years who do not have CSF leak, immunocompromising conditions or cochlear implant.4

When the vaccine providers and patients engage in shared clinical decision-making regarding the use of PCV13 vaccine in adults ≥65 years, they may consider to include the risk for pneumococcal disease for that person resulting from underlying medical conditions or the individual patient’s risk for exposure to PCV13 serotypes. The 2019 ACIP recommendations for the use of PCV13 and PPSV23 vaccines in adults aged 19 to 64 and ≥65 years are depicted in the table below.4

  

ACIP Recommendations for the Use of PCV13 and PPSV23 in Adults (Updated ACIP Recommendations. 2019.)4

Conclusion

  

In summary, the ACIP recommends considering regularly offering PCV13 to:

  •  Patients aged ≥65 years who have not previously received PCV13

  •  Persons residing in nursing homes or other long-term care facilities

  •  Persons residing in settings with low paediatric PCV13 uptake

  •  Persons traveling to settings with no paediatric PCV13 programme

  •  Patients aged ≥65 with chronic heart, lung or liver disease, diabetes or alcoholism, and those who smoke cigarettes or who have more than 1 chronic medical condition

According to the recent 2019 ACIP recommendations, shared clinical decision-making for PCV13 use for those persons aged ≥65 years is recommended, who have not received PCV13 previously and do not have CSF leak, immunocompromising condition or cochlear implant.4

  

  

ACIP, Advisory Committee on Immunization Practices; CSF, cerebrospinal fluid; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal.

References:

Tomczyk S, Bennett NM, Stoecker C, et al; Centers for Disease Control and Prevention. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 2014;63(37):822-825.Centers for Disease Control and Prevention. Licensure of 13-valent pneumococcal conjugate vaccine for adults aged 50 years and older. MMWR Morb Mortal Wkly Rep. 2012;61(21):394-395.Kobayashi M, Bennett NM, Gierke R, et al. Intervals between PCV13 and PPSV23 vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 2015;64(34):944-947.
Matanock A, Lee G, Gierke R, Kobayashi M, Leidner A, Pilishvili T. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: updated recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep. 2019;68(46):1069-1075.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

Recommendations for Use

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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