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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Axial Spondyloarthritis

Axial spondylitis: Ankylosing spondylitis

    

Enbrel® is approved across 6 indications, including paediatric indications.¹

  • Enbrel® is indicated for the treatment of adults with severely active axSpA who have had an inadequate response to conventional therapy1
     
  • Enbrel® is indicated for the treatment of adults with severe active AS who have had an inadequate response to conventional therapy1
     
  • Anti-TNF therapy of Enbrel® during routine clinical use improves disease activity and functional impairment in patients with AS2
     
  • Enbrel® improves nocturnal back pain and fatigue of patients with AS3
     
  • In patients with AS, Enbrel® shows significant reduction in the incidence of uveitis flares4
     
  • The ASAS group has published comprehensive, evidence-based consensus statements for the initiation of anti-TNF treatment in AS to identify appropriate therapeutic candidates5,6

    

Krishna

An RA patient considering starting a family Meet Krishna

Pradeep

An elderly-onset RA patient

 Meet Pradeep

Shiva

A young patient worried about the lifelong impact of RA Meet Shiva

Naidu

A young RA patient worried about treatments that lose effectiveness over time

 Meet Naidu

    

AS, ankylosing spondylitis; ASAS, Assessment of SpondyloArthritis international Society; axSpA, axial spondyloarthritis; CRP,
C-reactive protein; MRI, magnetic resonance imaging; NSAID, nonsteroidal anti-inflammatory drug; TNF, tumour necrosis factor.

References:

Enbrel. Local product document. Version LPDENB062021.Lord PA, Farragher TM, Lunt M, et al. Predictors of response to anti-TNF therapy in ankylosing spondylitis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford). 2010;49(3):563-570.Hammoudeh M, Zack DJ, Li W, Stewart VM, Koenig AS. Associations between inflammation, nocturnal back pain and fatigue in ankylosing spondylitis and improvements with etanercept therapy. J Int Med Res. 2013;41(4):1150-1159.Braun J, Baraliakos X, Listing J, Sieper J. Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. Arthritis Rheum. 2005;52(8):2447-2451.Davis JC, van der Heijde DM, Braun J, et al. Sustained durability and tolerability of etanercept in ankylosing spondylitis for 96 weeks. Ann Rheum Dis. 2005;64(11):1557-1562.Braun J, Pham T, Sieper J, et al. International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis. Ann Rheum Dis. 2003;62(9):817-824.

    

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

    

PP-ENB-IND-0814 August 2022

    
Therapeutic Indications
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