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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Psoriatic Arthritis

Enbrel® is approved across 6 indications, including paediatric indications.¹

  • Enbrel® is indicated for the reduction in signs and symptoms of active arthritis in patients with psoriatic arthritis1
     
  • Enbrel® has been shown to improve the physical function in patients with PsA and to reduce the rate of progression of peripheral joint damage, as measured by X-ray, in patients with polyarticular symmetrical subtypes (DIP joint involvement, polyarticular arthritis, arthritis mutilans, asymmetric peripheral arthritis, and ankylosing spondyli-tis-like arthritis) of the disease2

Enbrel® is among the approved and recommended biologics and small molecular therapies for PsA.1,3

   

   

Adapted from Lortholary O, et al. 2020;  Enbrel® LPD. Version LPDENB062021.

  • At the beginning of 2019, the ACR and the NPF released a joint guideline for the treatment of PsA4
     
  • The guideline highlights a conditional recommendation to use TNFi biologics over MTX as a first-line therapy in patients with active disease4

ACR/NPF Recommendations:
Management of Patients With Active PsA4

      

    

Adapted from Singh JA, et al. 2019.

    

Mahesh

A PsA patient with metabolic syndrome

 Meet Mahesh

Divya

A JIA patient moving from childhood to adulthood

 Meet Divya

   

ACR, American College of Rheumatology; DMARD, disease-modifying antirheumatic drug; IL, interleukin; JIA, juvenile idiopathic arthritis; MTX, methotrexate; NPF, National Psoriasis Foundation; PsA, psoriatic arthritis; TNF-α, tumour necrosis factor alpha; TNFi, tumour necrosis factor inhibitor.

   

References:

Enbrel. Local product document. Version LPDENB062021.Mease PJ, Kivitz AJ, Burch FX, et al. Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanercept. J Rheumatol. 2006;33(4):712-721.Lortholary O, Fernandez-Ruiz M, Baddley JW, Manuel O, Mariette X, Winthrop KL. Infectious complications of rheumatoid arthritis and psoriatic arthritis during targeted and biological therapies: a viewpoint in 2020. Ann Rheum Dis. 2020;79(12):1532-1543.Singh JA, Guyatt G, Ogdie A, et al. Special Article: 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the treatment of psoriatic arthritis. Arthritis Rheumatol. 2019;71(1):5-32.

   

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

    

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Therapeutic Indications
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