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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Juvenile Idiopathic Arthritis

Enbrel® is approved across 6 indications, including paediatric indications.¹

   

RF± polyarthritis and extended oligoarthritis

  • Enbrel® is indicated for the treatment of pJIA (RF±) and eoJIA in children aged 2 years and above and in adolescents1
Psoriatic arthritis
  • Enbrel® is indicated for the treatment of PsA in adolescents aged ≥12 years who have had an inadequate response to, or who have proven intolerance to, MTX1
Enthesitis-related arthritis
  • Enbrel® is indicated for the treatment of ERA in adolescents aged ≥12 years who have had an inadequate response to, or who have proven intolerance to, conventional therapy1
Enbrel® has not been studied in children aged <2 years.1

    

  • JIA is a heterogeneous group of conditions which encompasses all forms of arthritis of unknown aetiology lasting for at least 6 weeks and with onset before the age of 16 years2
  • Most common complications of JIA are leg-length discrepancy and joint contracture while an extremely fearsome complication is the macrophage activation syndrome3
  • Other important complications include growth retardation, low bone mineral density for chronologic age, severe hip involvement with the need of hip prosthesis and amyloidosis3
  • Etanercept provided sustained clinical benefit when used for up to 4 years in patients with JIA. ACR Pedi 30 scores at Year 1 were sustained through Year 4 of treatment with etanercept4

    

Safety and efficacy of etanercept in JIA after 13 years of treatment5

    

    Adapted from Bang MH, et al. 2019.
  • Drug survival rate after 13 years5:
     
    • 31% in systemic onset JIA patients
       
    • 84% in extended oligoarticular subtype
       
  • Drug survival after 10 years
     
    • 100% in RF+ polyarticular subtype
       
    • 80% in RF- polyarticular subtype
       
  • Drug survival after 5 years
     
    • 100% in ERA

Only 6 serious AEs (6.7%) during the 13-year period5

  

Retrospective data from 90 patients, 38 (42.0%) were male and 52 (58.0%) were female; 15 (16.7%) had systemic onset JIA, 41 (45.6%) had eoJIA, 14 (15.6%) had RF+ pJIA, 18 (20.0%) had RF− pJIA and 2 (2.1%) had ERA. Median age at the start of etanercept treatment was 9 years (range, 3-18 years), median duration of etanercept treatment was 6 years (range, 0.5-13 years).

  

 Vishala

A very young JIA patient

 Meet Vishala Dhruv

A JIA patient transitioning from childhood to adolescence

 Meet Dhruv

  

ACR Pedi, American College of Rheumatology Pediatric; AE, adverse event; eoJIA, extended oligoarticular juvenile idiopathic arthritis; ERA, enthesitis-related arthritis; JIA, juvenile idiopathic arthritis; MTX, methotrexate; PsA, psoriatic arthritis; pJIA, polyarticular juvenile idiopathic arthritis; RF+, rheumatoid factor positive; RF−, rheumatoid factor negative; RF±, rheumatoid factors positive or negative.

  

References:

Enbrel. Local product document. Version LPDENB062021.Giancane G, Consolaro A, Lanni S, Davì S, Schiappapietra B, Ravelli A. Juvenile idiopathic arthritis: diagnosis and treatment. Rheumatol Ther. 2016;3(2):187-207.Thatayatikom A, Modica R, De Leucio A. Juvenile Idiopathic Arthritis. StatPearls [Internet]. Accessed May 5, 2022. https://www.ncbi.nlm.nih.gov/books/NBK554605/Lovell DJ, Reiff A, Jones OY, et al. Long-term safety and efficacy of etanercept in children with polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum. 2006;54(6):1987-1994.Bang MH, Kim KN. Long-term safety and efficacy of etanercept in juvenile idiopathic arthritis in a single center. J Rheum Dis 2019;26:200-205.

  

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

    

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Therapeutic Indications
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